Lipoprotein immunogenetics and atherosclerosis.
Lipoprotein immunogenetics and atherosclerosis.
复制标题
脂蛋白免疫遗传学和动脉粥样硬化。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
J. Opitz
中科院分区：
文献类型：
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作者：
Jan Rapacz;J. Opitz
Allison和Blumberg发现了第一个人类脂蛋白多态[Lancet I：634-637,1961]，并发现了同种免疫血清，这促使我们开始对猪脂蛋白多样性及其与生物功能的关系进行免疫遗传学研究。我们在这个物种中发现了相当大的脂蛋白多态、复杂性和异质性。这些结果以及免疫定义的脂蛋白类型与高脂饲料喂养的猪的动脉脂肪沉积症的相关性进行了讨论。最近在恒河猴身上开始的脂蛋白的免疫遗传学研究也将被综述。初步数据显示，这两个物种在脂蛋白基因的多态性、复杂性、表型表达以及最重要的是它们与人类脂蛋白的血清学关系方面都有相似之处。我们还注意到其他研究人员或在其他物种中对脂蛋白进行的免疫遗传学研究。简要说明脂蛋白在动脉粥样硬化中的意义、它们的一般分类、免疫学特性以及在其研究中使用的免疫学方法。
The discovery of the first human lipoprotein polymorphism by Allison and Blumberg [Lancet i:634-637, 1961] and the availability of alloimmune sera stimulated us to begin immunogenetic studies on swine in search of lipoprotein diversity and its relationship to biological functions. We found considerable lipoprotein polymorphism, complexity, and heterogeneity in this species. These results and the correlation between immunogenetically defined lipoprotein type and arterial lipidosis in swine, fed a high fat diet, are discussed. Immunogenetic studies of lipoproteins, initiated more recently in rhesus monkeys, will be reviewed also. Preliminary data show similarities between these two species with regard to polymorphism, complexity, phenotypic expression of lipoprotein genes and, most importantly, their serological relationship to human lipoproteins. We also note immunogenetic studies on lipoproteins done by other investigators, or in other species. Brief remarks on implications of the lipoproteins in atherosclerosis, their general classification, immunological properties, and immunological methods used in their study precede the immunogenetic presentation.