Trends of Outpatient Prescription Drug Utilization in US Children, 2002-2010
Trends of Outpatient Prescription Drug Utilization in US Children, 2002-2010
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DOI：
10.1542/peds.2011-2879
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发表时间：
2012-07-01
期刊：
影响因子：
8
通讯作者：
Murphy, Dianne
中科院分区：
文献类型：
--
作者：
Chai, Grace;Governale, Laura;Murphy, Dianne
目的：描述2002年至2010年美国儿童门诊处方药使用的趋势以及儿科治疗使用主要领域的变化。方法：使用大型处方数据库（IMS Vector One: National and Total Patient Tracker）来检查2002年至2010年美国儿科人口（0-17岁）的全国药物使用模式。结果：2010年，美国儿科共发放了2.636亿张处方，比2002年减少了7%，而同期发放给成人的处方增加了22%。与2002年相比，2010年前12个治疗领域的儿科药物使用趋势分析显示，全身抗生素（-14%）、过敏（-61%）、疼痛（-14%）、抑郁（-5%）和咳嗽/感冒（-42%）处方减少，而哮喘（14%）、注意缺陷/多动障碍（46%）和避孕（93%）处方增加。2010年，阿莫西林是婴儿（0-23个月）和儿童（2-11岁）最常使用的处方。盐酸哌甲酯是12-17岁青少年的首选处方。确定了标签外使用，特别是兰索拉唑；2010年为婴儿开了35.8万张类似的处方
OBJECTIVE: To describe trends in outpatient prescription drug utilization in US children and the changes in major areas of pediatric therapeutic use for the years 2002 through 2010.METHODS: Large prescription databases (the IMS Vector One: National and Total Patient Tracker) were used to examine national drug utilization patterns for the US pediatric population (ages 0-17 years) from 2002 through 2010.RESULTS: In 2010, a total of 263.6 million prescriptions were dispensed to the US pediatric population, 7% lower than in 2002, while prescriptions dispensed to the adult population increased 22% during the same time. Analysis of pediatric drug utilization trends for the top 12 therapeutic areas in 2010 compared with 2002 showed decreases in systemic antibiotics (-14%), allergies (-61%), pain (-14%), depression (-5%), and cough/cold without expectorant (-42%) prescriptions, whereas asthma (14%), attention-deficit/hyperactivity disorder (46%), and contraceptive (93%) prescriptions increased. In 2010, amoxicillin was the most frequently dispensed prescription in infants (aged 0-23 months) and children (aged 2-11 years). Methylphenidate was the top prescription dispensed to adolescents (aged 12-17 years). Off-label use was identified, particularly for lansoprazole; similar to 358 000 prescriptions were dispensed in 2010 for infants