Serum PLGF as a potential biomarker for predicting the onset of preeclampsia
Serum PLGF as a potential biomarker for predicting the onset of preeclampsia
复制标题
DOI：
10.1007/s00404-011-1960-4
复制
发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
Agarwal, Sneh
中科院分区：
文献类型：
--
作者：
Ghosh, Sanjib Kumar;Raheja, Shashi;Agarwal, Sneh
先兆子痫是孕产妇和围产期发病率和死亡率的主要原因之一。迄今为止，尽管对这种情况进行了多年的研究，但预测子痫前期的发病仍然是一个问题。胎盘生长因子是众多血管生成因子之一，与正常妊娠相比，子痫前期胎盘生长因子水平显著改变。本研究旨在分析妊娠中期晚期血清PLGF水平是否可以作为先兆子痫的预测因子。共有150名在产前病房或产前诊所就诊的未分娩孕妇被纳入研究。她们被分为三组：30名血压正常的妇女和60名诊断为轻度和重度先兆子痫的妇女。对各研究组采集的血清样本进行ELISA检测，计算所有样本的血清PLGF水平。与正常妊娠相比，轻度和重度子痫前期的平均血清PLGF水平明显较低。血清PLGF水平在妊娠26-28周时最高，在妊娠28-30周和30-32周时降低。根据分析数据，统计计算血清PLGF水平预测轻、重度子痫前期的截止值。未产孕妇妊娠26周时血清PLGF水平的评估可作为筛查试验，以非常高的灵敏度识别有子痫前期发展风险的妇女。
Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality. Till date despite years of research into the condition, predicting the onset of preeclampsia remains a problem. Placental growth factor is one of the many angiogenic factors, which shows significant altered levels in preeclampsia compared to normal pregnancy. The present study aims to analyze whether estimation of serum PLGF levels in late second trimester can act as a predictor of preeclampsia.A total of 150 nulliparous pregnant women admitted in antenatal wards or attending antenatal clinic were included in the study. They were divided into three groups: 30 women being normotensive and 60 each with diagnosed mild and severe preeclampsia, respectively. Serum samples collected from the study groups were subjected to ELISA, and serum PLGF level was calculated in all the samples.Mean serum PLGF levels were found to be significantly low in mild and severe preeclampsia as compared to normal pregnancy. Serum PLGF levels were highest at 26-28 weeks and were lowered at 28-30 and 30-32 weeks of gestation within each of the three study groups. Cutoff value of serum PLGF levels for predicting mild and severe preeclampsia was calculated statistically from the analyzed data.Estimation of serum PLGF levels at 26 weeks of gestation in nulliparous pregnant women can be used as a screening test to identify women at risk for the development of preeclampsia with very high sensitivity.