Heterogeneity of endothelial function within the circulation.
Heterogeneity of endothelial function within the circulation.
复制标题
循环内内皮功能的异质性。
DOI：
10.1097/00041552-199801000-00012
复制
发表时间：
1998
影响因子：
3.2
通讯作者：
Boegehold,MA
中科院分区：
文献类型：
--
作者：
Boegehold,MA
随着我们对内皮功能认识的不断深入，随着内皮细胞层对血管张力的影响，外周血管表现出明显的区域性和节段性异质性。这种异质性不仅包括内皮衍生因子和血管平滑肌之间的正常相互作用，还包括这些相互作用在幼年生长过程中或高血压等疾病中发生变化的方式。这种异质性的潜在原因是多因素的，包括内皮细胞群体之间的内在差异和内皮细胞微环境的差异。
As our understanding of endotnelial function continues to evolve, it has become increasingly clear that the peripheral vasculature exhibits striking regional and segmental heterogeneity in the influence of the endothelial cell layer on vascular tone. This heterogeneity encompasses not only the normal interactions between endothelium-derived factors and vascular smooth muscle, but also: the way in which these interactions can change during juvenile growth or in disease such as hypertension. The underlying causes of this heterogeneity are multifactorial and include intrinsic differences among endothelial cell populations and differences in the endothelial cell microenvironment.