Human immunodeficiency virus antigenemia in patients with AIDS and AIDS-related disorders: a comparison between European and Central African populations.
Human immunodeficiency virus antigenemia in patients with AIDS and AIDS-related disorders: a comparison between European and Central African populations.
复制标题
艾滋病和艾滋病相关疾病患者的人类免疫缺陷病毒抗原血症：欧洲和中非人群的比较。
DOI：
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发表时间：
1987
影响因子：
6.4
通讯作者：
A. Goudeau
中科院分区：
文献类型：
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作者：
A. Baillou;F. Barin;J. Allain;E. Petat;P. Kocheleff;P. Kadende;A. Goudeau
对1983年1月至1987年1月收集的80份法国血清和1984年11月至1986年4月从布隆迪布琼布拉采集的117份血清进行了HIV抗原和抗HIV核心蛋白p24抗体的检测。法国受试者包括21名艾滋病患者、23名ARC患者和36名无症状的HIV阳性患者。布隆迪人中有40名艾滋病患者、40名ARC患者和37名无症状的HIV阳性患者。所有的血清都被冷冻起来，直到同时在法国巡回赛进行检测。用含有p17和p15片段的核心蛋白p24的酶联免疫吸附试验试剂盒(Enacore Abbott)筛选HIV抗体。在欧洲血清中，艾滋病病毒抗原从无症状HIV阳性者的2.8%上升到ARC患者的21.7%，上升到艾滋病患者的47.6%。23.8%的艾滋病患者、78.9%的ARC患者和86.1%的血清阳性者检出抗体。抗Gag抗原抗体与缺乏HIV抗原血症有关：有抗体的人中有1.9%的人患有循环中的HIV；无抗体的人中有55.6%的人患有HIV。在布隆迪的血清中，97.3%的ARC患者和90.0%的艾滋病患者血清中检出了HIV抗体。40例艾滋病患者中只有1例(2.5%)感染了HIV，其他组均为阴性。因此，欧洲人得出的抗体与症状严重程度成反比的结论在这群中非人中是站不住脚的。
HIV antigens and antibodies against the HIV core protein p24 were assayed in 80 French sera collected from January 1983-January 1987 and 117 sera from Bujumbura Burundi taken from November 1984-April 1986. The French subjects were 21 people with AIDS 23 with ARC and 36 asymptomatic HIV-positive people. The Burundians were 40 with AIDS 40 with ARC and 37 HIV-positive asymptomatic people. All sera were frozen until testing in Tours France at the same time. HIV antibodies were screened with an ELISA kit (Envacore Abbott) which employed the core protein p24 with fragments of p17 and p15. In The European sera AIDS viral antigens rose from 2.8% of asymptomatic HIV-positives to 21.7% of those with ARC to 47.6% of AIDS patients. Antibodies were found in 23.8% of patients with AIDS 78.9% of those with ARC and 86.1% of seropositive persons. Antibodies against gag antigens were associated with lack of HIV antigenemia: 1.9% with antibodies had circulating HIV; 55.6% of those without antibodies had HIV. In sera from Burundi HIV antibodies were detected in 97.3% of seropositives 90.0 of those with ARC and 90.0% with AIDS. Only 1 of 40 (2.5%) of the AIDS patients and none of those in the other groups had circulating HIV. Thus the generalization made in Europeans that antibodies are inversely related to severity of symptoms does not hold in this group of central Africans.