Golimumab-associated persistent erythema multiforme in a patient with ulcerative colitis in full remission.
Golimumab-associated persistent erythema multiforme in a patient with ulcerative colitis in full remission.
复制标题
完全缓解的溃疡性结肠炎患者与戈利木单抗相关的持续性多形红斑。
作者：
G. Badavanis;Efstathia Pasmatzi;N. Kapranos;A. Monastirli;D. Tsambaos
多形性红斑是一种免疫介导的皮肤疾病，被认为是对感染、药物、疫苗、恶性肿瘤、自身免疫性疾病、辐射和月经的超敏反应。戈利木单抗是一种人IgG 1-κ抗TNF抗体，已被批准用于治疗类风湿性关节炎、银屑病关节炎、强直性脊柱炎和溃疡性结肠炎。我们在此报告一位41岁女性，持续性多形性红斑，发生在戈利木单抗治疗溃疡性结肠炎后18个月，后者在36个月内保持完全缓解。
Erythema multiforme is an immune-mediated cutaneous disorder that is thought to represent a hypersensitivity reaction to infections, drugs, vaccines, malignancies, autoimmune diseases, radiation, and menstruation. Golimumab is a human IgG1-kappa anti-TNF antibody that has been approved for the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. We report herein a 41-year-old woman with persistent erythema multiforme, that occurred 18 months after onset of golimumab treatment of her ulcerative colitis; the latter remains in full remission over a period of 36 months.