In vivo positron of progression-emission tomography imaging of progression and transformation in model of mammary neoplasia
In vivo positron of progression-emission tomography imaging of progression and transformation in model of mammary neoplasia
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DOI：
10.1073/pnas.0404396101
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发表时间：
2004-08-03
影响因子：
11.1
通讯作者：
Cherry, SR
中科院分区：
文献类型：
--
作者：
Abbey, CK;Borowsky, AD;Cherry, SR
人类癌症的小鼠模型成像有望更有效地分析肿瘤进展，并减少临床前治疗干预试验中统计能力所需的动物数量。本研究利用2-[F-18]-氟脱氧-d -葡萄糖的正电子发射断层成像来监测免疫功能正常的FVB/NJ小鼠乳腺上皮内肿瘤生长的纵向发展。乳腺上皮内瘤变的生长组织模拟了乳腺癌从癌前导管原位癌到浸润性癌的进展。疾病的进展在正电子发射断层图像中清晰可见，示踪剂摄取与组织学评估相关。此外，从图像中提取的疾病定量标记物可用于跟踪多个时间点的体内增殖和进展。
Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[F-18]-fluoro-deoxy-D-glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.