Combination of two cytokine inhibitors reduces nucleus pulposus-induced nerve injury more than using each inhibitor separately.
Combination of two cytokine inhibitors reduces nucleus pulposus-induced nerve injury more than using each inhibitor separately.
复制标题
两种细胞因子抑制剂的组合比单独使用每个抑制剂降低了核核诱导的神经损伤。
DOI：
10.2174/1874325001105010151
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发表时间：
2011-04-28
期刊：
影响因子：
--
通讯作者：
Olmarker K
中科院分区：
文献类型：
--
作者：
Olmarker K
虽然最近的实验研究表明，椎间盘衍生的细胞因子，如TNF，似乎密切参与坐骨神经痛和腰痛的病理生理学，进行的临床研究没有提供结论性的数据，TNF抑制作为一个有用的补充，治疗这些条件，现有的方式。基于TNF仅仅是复杂网络中的一个组分的事实，假设TNF抑制剂和IL-1β抑制剂的组合可以增强猪模型中对髓核诱导的神经传导速度降低的作用。数据表明，两种细胞因子抑制剂的组合似乎比单独使用每种抑制剂更有效地减少髓核诱导的对神经传导速度的影响。如果未来仅使用单一抑制剂治疗坐骨神经痛和下背痛的临床试验可能继续显示不确定的数据，则可以考虑这一点。
Although recent experimental studies indicate that disc-derived cytokines, as for instance TNF, seems to be intimately involved in the pathophysiology of sciatica and low back pain, the clinical studies performed do not provide conclusive data on TNF-inhibition as a useful complement for treatment of such conditions to existing modalities. Based on the fact that TNF is merely one component in a complex network it was assumed that the combination of a TNF-inhibitor and an IL-1β-inhibitor could potentiate the effects in a pig model on nucleus pulposus-induced nerve conduction velocity reduction. The data indicated that combination of two cytokine inhibitors seems to be more efficient in reducing the nucleus pulposus-induced effects on nerve conduction velocity than using each inhibitor separately. This may be considered if future clinical trials for the treatment of sciatica and low back pain using just a single inhibitor may continue to demonstrate inconclusive data.