[Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor].
[Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor].
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睾丸肿瘤治疗过程中产生的肺横纹肌肉瘤[J].
DOI：
10.5980/jpnjurol1989.94.696
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
H. Ishida
中科院分区：
文献类型：
--
作者：
M. Kita;Yutaka Sasaki;M. Okuyama;Y. Saga;H. Hashimoto;S. Kaneko;S. Yachiku;M. Tokumitsu;F. Inada;H. Ishida
一位23岁男性因肺转移瘤入院治疗。他在前一年接受了右侧高位睾丸切除术、四个疗程的PEB方案化疗（顺铂、依托泊苷、博莱霉素）和腹膜后淋巴结清扫术。病理结果显示睾丸混合性生殖细胞瘤（睾丸母细胞瘤、卵黄囊瘤、胚胎癌）和引流淋巴结成熟畸胎瘤。诊断肺转移后，使用VIP方案（依托泊苷、异环磷酰胺、顺铂）进行了两个疗程的挽救化疗，但对肿瘤大小没有影响。然后进行了电视辅助肺转移瘤切除术，在所有三个切除的肿瘤中给出了横纹肌肉瘤的病理诊断。手术后进行了三个疗程的CYVADIC（环磷酰胺，长春新碱，阿霉素，达卡巴嗪）化疗和口服环磷酰胺，因为怀疑有小的残留肿瘤。这些化疗干预似乎是有效的，目前没有明显的复发病灶，切除肺转移瘤后一年。
A 23-year-old male was admitted to our hospital for the management of pulmonary metastases. He had undergone right high orchiectomy, chemotherapy with four courses of PEB regimen (cisplatin, etoposide, bleomycin) and retroperitoneal lymph node dissection the previous year. The pathological findings showed mixed germ cell tumor (seminoma, yolk sac tumor, embryonal carcinoma) in the testis and mature teratoma in the draining lymph node. Two courses of salvage chemotherapy using a VIP regimen (etoposide, ifosfamide, cisplatin) were performed after diagnosis of pulmonary metastases, but had no affect on tumor size. Video-assisted excision of pulmonary metastases was then performed, giving a pathological diagnosis of rhabdomyosarcoma in all three resected tumors. The operation was followed by three courses of CYVADIC (cyclophosphamide, vincristine, adriamycin, dacarbazin) chemotherapy and oral cyclophosphamide, as a small residual tumor was suspected. These chemotherapeutic interventions have appeared effective, with no apparent recurrence of lesions at present, one year after the excision of pulmonary metastases.