Cancer in the Fourth Dimension: What Is the Impact of Circadian Disruption?
Cancer in the Fourth Dimension: What Is the Impact of Circadian Disruption?
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DOI：
10.1158/2159-8290.cd-20-0413
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发表时间：
2020-10
期刊：
影响因子：
28.2
通讯作者：
Lamia KA
中科院分区：
文献类型：
--
作者：
Pariollaud M;Lamia KA
昼夜节律整合了许多生理途径，帮助生物体将各种内部过程的时间与外部环境的日常周期保持一致。昼夜节律紊乱是现代社会的一个显著特征，并已被指定为可能的致癌物。在这里，我们回顾了在人类和动物模型中的多项研究，这些研究表明昼夜节律紊乱和癌症风险增加之间存在因果关系。我们还讨论了这种连接的复杂性，这可能取决于细胞环境。
Circadian rhythms integrate many physiological pathways, helping organisms to align the timing of various internal processes to daily cycles in the external environment. Disrupted circadian rhythmicity is a prominent feature of modern society, and has been designated as a probable carcinogen. Here we review multiple studies, in humans and animal models, that suggest a causal effect between circadian disruption and increased risk of cancer. We also discuss the complexity of this connection, which may depend on the cellular context.