Retinoids in lung development
Retinoids in lung development
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DOI：
10.1096/fasebj.10.9.8801181
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发表时间：
1996-07-01
期刊：
影响因子：
4.8
通讯作者：
Chytil, F
中科院分区：
文献类型：
--
作者：
Chytil, F
“类维生素性革命”对肺发育领域的研究活动产生了相当大的影响，产后肺对饮食中的视黄醇（R）剥夺非常敏感。 R缺陷动物中的气管和支气管肺树显示形态的发生了惊人的变化。柱状上皮经历角质化的质量，在提供R时会逆转。胎儿肺在产后发展成为最复杂的器官之一，其特征在于40种不同的细胞类型，胎儿肺可以累积视黄酯，在出生前，未知的信号会导致这些酯的降低，这可能是视β酯的来源（这可能是视β的来源（ RA）。糖皮质激素的施用加快了这一过程，进而加速了肺部成熟，以后结束。目前尚不清楚在这种现象中的细胞性类动物结合蛋白在这种现象中起什么作用，胎儿肺分支导致肺泡树发育的发展，RA会加速，因此某些编码表面活性剂蛋白和表面活性剂蛋白和表达的胎儿基因的表达也是如此。产生其脂质成分的酶，尚不清楚RA是否通过直接与上皮相互作用会影响肺上皮的发展细胞或其作用是否需要与其他细胞（例如间充质细胞）相互作用，尽管有大量证据表明维生素A在临床工作中的应用已限于过早分娩的患有未成熟肺部的婴儿。在这里，通过改善其R状态来进行尝试，以帮助氧疗法受伤的肺部发育和康复。
The ''retinoid revolution'' has had considerable impact on research activity in the field of lung development, Postnatal lungs are very sensitive to dietary retinol (R) deprivation. The trachea and the bronchopulmonary tree in R-deficient animals show a striking change in morphology. The columnar epithelium undergoes keratinizing metaplasia, which is reversed when R is supplied. The fetal lung develops postnatally to become one of the most complex organs, characterized by 40 different cell types, The fetal lungs can accumulate retinyl esters, Before birth an unknown signal causes the lowering of these esters, which may be the source of retinoic acid (RA). The administration of glucocorticoids speeds up this process, which in turn is followed by acceleration of lung maturation, ending postnatally. It is not clear what role, if any, the cellular retinoid binding proteins play in this phenomenon, Fetal lung branching leading to the development of the alveolar tree is accelerated by RA, and so is the expression of some fetal genes coding for surfactant proteins and the enzymes that produce their lipid components, It is not clear whether RA influences the development of pulmonary epithelium by interacting directly with the epithelial cells or whether its effects require interaction with other cells like mesenchymal cells, Nuclear RA receptors are intimately involved in lung development, Despite the wealth of evidence on the effect of retinoids on lung development, the application of vitamin A to clinical work has been Limited to prematurely delivered infants who have immature lungs. Here attempts are made, by improving their R status, to aid in the development and healing of lungs injured by oxygen therapy.