Sensing Stemness.
Sensing Stemness.
复制标题
DOI：
10.1007/s40778-021-00201-w
复制
发表时间：
2021
影响因子：
1.4
通讯作者：
Trompouki E
中科院分区：
文献类型：
--
作者：
Bowman TV;Trompouki E
造血干细胞(HSCs)是在动态发育过程中以胚胎的形式形成的，之后以静止状态存在于成人的造血器官中。为了应对不断变化的环境，人类干细胞进化出了不同的机制来应对内在和外在的挑战。这篇综述旨在讨论HSCs和其他干细胞如何利用DNA和RNA先天免疫途径来微调发育过程。与生俱来的核酸免疫受体，如Rig-I-like家族受体和DNA传感通路的成员，在造血干细胞和其他干细胞中表达。尽管这些受体的“经典”作用是识别病原体中的外源DNA或RNA，但最近的研究表明，细胞转座元件(TE)RNA或R环激活了这些受体，作为内源性炎症信号的触发因素，可以在发育和再生过程中塑造HSC的形成。内源性TES和R环激活RNA和DNA传感器，从而触发不同的炎症信号来微调干细胞的决定。这一现象可能会对不同的体细胞干细胞、各种疾病和衰老过程产生广泛的影响。
Hematopoietic stem cells (HSCs) are formed embryonically during a dynamic developmental process and later reside in adult hematopoietic organs in a quiescent state. In response to their changing environment, HSCs have evolved diverse mechanisms to cope with intrinsic and extrinsic challenges. This review intends to discuss how HSCs and other stem cells co-opted DNA and RNA innate immune pathways to fine-tune developmental processes. Innate immune receptors for nucleic acids like the RIG-I-like family receptors and members of DNA sensing pathways are expressed in HSCs and other stem cells. Even though the “classic” role of these receptors is recognition of foreign DNA or RNA from pathogens, it was recently shown that cellular transposable element (TE) RNA or R-loops activate such receptors, serving as endogenous triggers of inflammatory signaling that can shape HSC formation during development and regeneration. Endogenous TEs and R-loops activate RNA and DNA sensors, which trigger distinct inflammatory signals to fine-tune stem cell decisions. This phenomenon could have broad implications for diverse somatic stem cells, for a variety of diseases and during aging.
登录
查看更多内容
影响因子：
56.9
作者：
Bauernfried, Stefan;Scherr, Matthias J.;Hornung, Veit
通讯作者：
Hornung, Veit
影响因子：
23.9
作者：
Avgustinova, Alexandra;Laudanna, Carmelo;Benitah, Salvador Aznar
通讯作者：
Benitah, Salvador Aznar
影响因子：
21.3
作者：
Glück S;Guey B;Gulen MF;Wolter K;Kang TW;Schmacke NA;Bridgeman A;Rehwinkel J;Zender L;Ablasser A
通讯作者：
Ablasser A
DOI：
10.4049/jimmunol.1701492
发表时间：
2018-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brault M;Olsen TM;Martinez J;Stetson DB;Oberst A
通讯作者：
Oberst A
影响因子：
64.8
作者：
Chelmicki, Tomasz;Roger, Emeline;Bourc'his, Deborah
通讯作者：
Bourc'his, Deborah