Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development.
Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development.
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DOI：
10.3390/toxics2010017
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发表时间：
2014
期刊：
影响因子：
4.6
通讯作者：
Mangum LC
中科院分区：
文献类型：
--
作者：
Ross MK;Matthews AT;Mangum LC
化学动脉粥样硬化是一个新兴领域，描述了环境污染物和内源性毒素如何干扰调节脂质代谢和炎症的关键途径，从而损伤血管壁内的细胞。尽管人们越来越意识到环境污染物在心血管疾病发展中的作用，但化学动脉粥样硬化的领域可以广泛地包括外源性和内源性毒物，以及对动脉粥样硬化过程中失调的分子、生化和细胞途径的研究。这种综合方法是合乎逻辑的，因为外源性和内源性毒素通常具有相同的毒性机制。化学动脉粥样硬化是一门真正的综合性学科，因为它融合了几个不同领域的概念，包括生物化学、化学生物学、药理学和毒理学。这篇综述将提供这一新兴研究领域的概述，重点是疾病的细胞和动物模型。
Chemical atherogenesis is an emerging field that describes how environmental pollutants and endogenous toxins perturb critical pathways that regulate lipid metabolism and inflammation, thus injuring cells found within the vessel wall. Despite growing awareness of the role of environmental pollutants in the development of cardiovascular disease, the field of chemical atherogenesis can broadly include both exogenous and endogenous poisons and the study of molecular, biochemical, and cellular pathways that become dysregulated during atherosclerosis. This integrated approach is logical because exogenous and endogenous toxins often share the same mechanism of toxicity. Chemical atherogenesis is a truly integrative discipline because it incorporates concepts from several different fields, including biochemistry, chemical biology, pharmacology, and toxicology. This review will provide an overview of this emerging research area, focusing on cellular and animal models of disease.