Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.
Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.
复制标题
皮质回路的协调变化塑造了新奇事物对神经动力学的影响。
DOI：
10.1101/2023.10.21.563440
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Arkhipov,Anton
中科院分区：
文献类型：
--
作者：
Ito,Shinya;Piet,Alex;Bennett,Corbett;Durand,Séverine;Belski,Hannah;Garrett,Marina;Olsen,ShawnR;Arkhipov,Anton
最近的研究发现了对新奇刺激的戏剧性细胞类型特异性反应，强调了在这种粒度上分析皮层回路对理解大脑功能的重要性。尽管最初的研究以细胞类型为特征，但由于相互作用的新奇效应而引起的皮层回路的改变仍不清楚。我们使用行为小鼠的电生理记录的大规模公共数据集和种群网络模型研究了观察到的神经动力学响应新刺激的电路机制。该模型受到多斑块突触生理学和电镜数据的约束。我们发现，在新的刺激下，生长抑素（SST）和血管活性肠多肽（VIP）种群之间的平衡发生了变化，对小白蛋白（PV）和SST种群的兴奋性影响增加，这种联系普遍较弱。这些发现系统地描述了皮层回路如何适应新的刺激。
Recent studies have found dramatic cell-type-specific responses to stimulus novelty, highlighting the importance of analyzing the cortical circuitry at this granularity to understand brain function. Although initial work characterized activity by cell type, the alterations in cortical circuitry due to interacting novelty effects remain unclear. We investigated circuit mechanisms underlying the observed neural dynamics in response to novel stimuli using a large-scale public dataset of electrophysiological recordings in behaving mice and a population network model. The model was constrained by multi-patch synaptic physiology and electron microscopy data. We found generally weaker connections under novel stimuli, with shifts in the balance between somatostatin (SST) and vasoactive intestinal polypeptide (VIP) populations and increased excitatory influences on parvalbumin (PV) and SST populations. These findings systematically characterize how cortical circuits adapt to stimulus novelty.