Diffuse interface model for cell interaction and aggregation with Lennard-Jones type potential
Diffuse interface model for cell interaction and aggregation with Lennard-Jones type potential
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DOI：
10.1016/j.cma.2023.116257
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发表时间：
2023-10
影响因子：
7.2
通讯作者：
Lingyue Shen;P. Lin;Zhiliang Xu;Shixin Xú
中科院分区：
文献类型：
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作者：
Lingyue Shen;P. Lin;Zhiliang Xu;Shixin Xú
本文介绍了一个相场模型，该模型旨在模拟有限空间域内流动条件下多细胞系统的相互作用和聚集。该模型采用了多维Lennard-Jones势来解释细胞之间的短程排斥和粘合。为了求解控制方程，同时保持能量定律，二阶精度C 0有限元方法。通过数值试验验证了模型的有效性，并利用细胞拉伸试验数据对模型进行了标定和验证。此外，该研究还调查了红细胞中不同粘附特性的影响。总的来说，这项工作提出了一个在流动条件下模拟细胞-细胞和细胞-壁相互作用的理论上一致和计算上有效的框架。
This study introduces a phase-field model designed to simulate the interaction and aggregation of multicellular systems under flow conditions within a bounded spatial domain. The model incorporates a multi-dimensional Lennard-Jones potential to account for short-range repulsion and adhesive bonding between cells. To solve the governing equations while preserving energy law, a second-order accurate C 0 finite element method is employed. The validity of the model is established through numerical tests, and experimental data from cell stretch tests is utilized for model calibration and validation. Additionally, the study investigates the impact of varying adhesion properties in red blood cells. Overall, this work presents a thermodynamically consistent and computationally efficient framework for simulating cell–cell and cell–wall interactions under flow conditions.