A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-Chloroglycine).
A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-Chloroglycine).
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用 GK-101（N-氯甘氨酸）处理后胶原蛋白和羟脯氨酸的化学评估。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
M. Goldman
中科院分区：
文献类型：
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作者：
C. M. Habib;J. Kronman;M. Goldman
研究了GK-101（N-氯甘氨酸）与胶原蛋白和羟脯氨酸的反应，以及其去龋作用。与N-氯甘氨酸反应后，通过碘量滴定法分析胶原蛋白的结合有效氯，并通过PAB处理后产生红色色原来测量羟脯氨酸向吡咯-2-羧酸的转化。结果表明，N-氯代甘氨酸对胶原进行了氯化，羟脯氨酸经氯化反应生成吡咯-2-羧酸。这些发现往往表明两种可能的途径N-氯甘氨酸蛋白相互作用。
The reactions of GK-101 (N-chloroglycine) with collagen and hydroxyproline, were studied with regard to caries removal. After reaction with N-chloroglycine, collagen was analyzed for bound available chlorine by iodiometric titration, and hydroxyproline conversion to pyrrole-2-carboxylic acid was measured by they production of a red chromogen after PAB treatment. The results indicated that collagen was chlorinated by N-chloroglycine and hydroxyproline was converted to pyrrole-2-carboxylic acid after N-chloroglycine reaction. These findings tend to indicate two possible pathways of N-chloroglycine protein interaction.