INVITRO COMPARISON OF THE SELECTIVITY OF ELECTRODES FOR INVIVO ELECTROCHEMISTRY
INVITRO COMPARISON OF THE SELECTIVITY OF ELECTRODES FOR INVIVO ELECTROCHEMISTRY
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DOI：
10.1016/0165-0270(84)90058-x
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发表时间：
1984-01-01
影响因子：
3
通讯作者：
WIGHTMAN, RM
中科院分区：
文献类型：
--
作者：
KOVACH, PM;EWING, AG;WIGHTMAN, RM
4种类型的碳电极设计用于在体内传感器的哺乳动物大脑中容易氧化的物种在生理pH值的水溶液中进行了评价的性能。电极是由石墨-环氧树脂混合物，碳糊，或碳纤维，并具有磁盘或圆柱体的几何形状。几种儿茶酚胺，它们的一些代谢产物和前体，尿酸，和抗坏血酸的伏安特性在未改性的碳表面的报告。抗坏血酸和儿茶酚的伏安波重叠的问题得到解决，并检查2种不同的方法，最大限度地减少这个问题。这些是使用由碳纤维制成的盘形电极，其便于使用减法伏安图来确定在抗坏血酸存在下的儿茶酚胺浓度的微小变化，以及使用也由碳纤维制成的电化学改性的圆柱形电极。 在修饰电极上的伏安法给出了证据，邻苯二酚可以从抗坏血酸中分离出来，并且邻苯二酚，而不是抗坏血酸，吸附到电极表面。
The properties of 4 types of carbon electrodes designed for use as in vivo sensors of easily oxidized species in the mammalian brain were evaluated in aqueous solutions at physiological pH. The electrodes are formed from a graphite-epoxy mixture, carbon paste, or carbon fibers, and have the geometries of a disk or a cylinder. The voltammetric properties of several catecholamines, some of their metabolites and precursors, uric acid, and ascorbic acid are reported at unmodified carbon surfaces. The problem of overlap of the voltammetric waves of ascorbate and catechols is addressed, and 2 different methods which minimize this problem are examined. These are the use of disk-shaped electrodes fabricated from carbon fibers, which facilitate the use of subtracted voltammograms to determine small changes in the concentration of catecholamines in the presence of ascorbic acid, and the use of electrochemically modified, cylindrically-shaped electrodes also fabricated from carbon fibers. Voltammetry at the modified electrodes gives evidence the catechols can be resolved from ascorbate, and that catechols, but not ascrobic acid, adsorb to the electrode surface.