QUISQUALATE ACTIVATES A RAPIDLY INACTIVATING HIGH CONDUCTANCE IONIC CHANNEL IN HIPPOCAMPAL-NEURONS
QUISQUALATE ACTIVATES A RAPIDLY INACTIVATING HIGH CONDUCTANCE IONIC CHANNEL IN HIPPOCAMPAL-NEURONS
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DOI：
10.1126/science.2467378
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发表时间：
1989-03-17
期刊：
影响因子：
56.9
通讯作者：
MORAD, M
中科院分区：
文献类型：
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作者：
TANG, CM;DICHTER, M;MORAD, M
谷氨酸激活了许多不同的受体-通道复合体，每个复合体都可能参与哺乳动物中枢神经系统兴奋性突触后电位的产生。选择性谷氨酸激动剂Quisqualate的快速应用激活了一个大的快速失活电流(3-8毫秒)，该电流是由一个具有高单位电导的神经元离子通道(35皮秒)介导的。通过该通道的电流表现出与快速兴奋性突触后电流(EPSC)相似的药理学特征；它在0毫伏附近反转，没有明显的电压依赖性。通过该通道的电流幅度比通过其他非NMDA(N-甲基-D-天冬氨酸)通道的电流幅度大许多倍。这些结果表明，这种高电导的准激活通道可能介导了哺乳动物中枢神经系统的快速EPSC。
Glutamate activates a number of different receptor-channel complexes, each of which may contribute to generation of excitatory postsynaptic potentials in the mammalian central nervous system. The rapid application of the selective glutamate agonist, quisqualate, activates a large rapidly inactivating current (3 to 8 milliseconds), which is mediated by a neuronal ionic channel with high unitary conductance (35 picosiemens). The current through this channel shows pharmacologic characteristics similar to those observed for the fast excitatory postsynaptic current (EPSC); it reverses near 0 millivolts and shows no significant voltage dependence. The amplitude of the current through this channel is many times larger than that through the other non-NMDA (N-methyl-D-aspartate)channels. These results suggest that this high-conductance quisqualate-activated channel may mediate the fast EPSC in the mammalian central nervous system.