The signaling pathways that mediate the anti-cancer effects of caloric restriction
The signaling pathways that mediate the anti-cancer effects of caloric restriction
复制标题
介导热量限制抗癌作用的信号通路
DOI：
10.1016/j.phrs.2019.01.021
复制
发表时间：
2019
影响因子：
9.3
通讯作者：
Tang Kai Fu
中科院分区：
文献类型：
--
作者：
Lu Yiyi;Tao Fengxing;Zhou Meng Tao;Tang Kai Fu
热量限制（CR）已被证明可以促进长寿和改善衰老相关疾病，包括癌症。近几十年来的广泛研究表明，CR减少IGF-1/PI 3 K/AKT信号传导并增加sirtuin信号传导。我们最近发现，CR还增强ALDOA/DNA-PK/p53信号传导。本文综述了CR对IGF-1/PI 3 K/AKT通路、sirtuin信号通路和ALDOA/DNA-PK/p53通路的调控机制。我们还总结了有关这些信号通路在致癌作用中的证据，并讨论了它们是如何被CR调节的。最后，我们讨论了这些信号通路之间的串扰。
Caloric restriction (CR) has been shown to promote longevity and ameliorate aging-associated diseases, including cancer. Extensive research over recent decades has revealed that CR reduces IGF-1/PI3K/AKT signaling and increases sirtuin signaling. We recently found that CR also enhances ALDOA/DNA-PK/p53 signaling. In the present review, we summarize the molecular mechanisms underlying the modulation of the IGF-1/PI3K/AKT pathway, sirtuin signaling, and the ALDOA/DNA-PK/p53 pathway by CR. We also summarize the evidence concerning the roles of these signaling pathways in carcinogenesis, and discuss how they are regulated by CR. Finally, we discuss the crosstalk between these signaling pathways.