Chemokine CXC Ligand 13 in Cerebrospinal Fluid Can Be Used as an Early Diagnostic Biomarker for Lyme Neuroborreliosis: A Meta-Analysis
Chemokine CXC Ligand 13 in Cerebrospinal Fluid Can Be Used as an Early Diagnostic Biomarker for Lyme Neuroborreliosis: A Meta-Analysis
复制标题
脑脊液中的趋化因子 CXC 配体 13 可用作莱姆神经疏螺旋体病的早期诊断生物标志物：荟萃分析
DOI：
10.1089/jir.2016.0101
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发表时间：
2017
影响因子：
2.3
通讯作者：
Dai Xiting
中科院分区：
文献类型：
--
作者：
Yang Jiaru;Han Xinlin;Liu Aihua;Bao Fukai;Peng Yun;Tao Lueyan;Ma Mingbiao;Bai Ruolan;Dai Xiting
莱姆病神经疏螺旋体病（LNB）是莱姆病（LD）最常见的神经系统表现，严重损害中枢和外周神经系统。目前LNB的诊断方法和标准不是很有效。近年来，一些研究表明，脑脊液（CSF）中高浓度的趋化因子CXC配体13（CXCL 13）可作为诊断LNB的新生物标志物。因此，我们进行了一项荟萃分析，系统地分析了这些研究的数据，以评估CXCL 13作为LNB生物标志物的价值。在多个数据库（包括PubMed、Embase、科克伦图书馆和中国知网（CNKI））中检索文章后，我们在荟萃分析中纳入了7篇文章，共1299例LNB或其他神经炎性疾病患者。在这1299名患者中，343名LNB患者作为实验组，956名其他神经炎性疾病患者或健康个体作为对照组。采用Meta-Disc 1.4统计软件进行分析。基于合并的特异性、敏感性、阳性似然比、阴性似然比、诊断比值比和汇总受试者工作特征曲线，我们发现CXCL 13确实具有诊断LNB的高敏感性和特异性，这意味着它可以用作诊断LNB的新的诊断生物标志物。
Lyme neuroborreliosis (LNB), which is the most common neurological manifestation of Lyme disease (LD), seriously impairs both the central and peripheral nervous systems. Current LNB diagnostic methods and criteria are not very effective. Recently, several studies have indicated that a high concentration of the chemokine CXC ligand 13 (CXCL13) in cerebrospinal fluid (CSF) could be used as a new biomarker for the diagnosis of LNB. Thus, we carried out a meta-analysis to systematically analyze the data from these studies to evaluate the value of CXCL13 as an LNB biomarker. After searching for articles in several databases, including PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure (CNKI), we included 7 articles in the meta-analysis with a total of 1299 patients with LNB or other neuroinflammatory diseases. From these 1299 patients, 343 patients with LNB served as the experimental group and 956 patients with other neuroinflammatory diseases or healthy individuals served as the control group. The analyses were performed using Meta-Disc1.4 statistical software. Based on the pooled specificity, sensitivity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and summary receiver operating characteristic curve, we found that CXCL13 indeed has a high sensitivity and specificity for diagnosing LNB, which means that it can be used as a new diagnostic biomarker for the diagnosis of LNB.