Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment
Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment
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DOI：
10.1016/s0140-6736(06)68426-2
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发表时间：
2006-03-25
期刊：
影响因子：
168.9
通讯作者：
Weil, GJ
中科院分区：
文献类型：
--
作者：
Ramzy, RMR;El Setouhy, M;Weil, GJ
背景 埃及是最早实施消除淋巴丝虫病国家计划的国家之一，该计划基于世界卫生组织的战略，即使用二乙基卡马嗪和阿苯达唑进行多次大规模药物管理（MDA）（目标人群：181 个地区的 250 万）。我们评估了埃及四个哨点村庄每年五轮MDA对丝虫病的影响。方法我们研究了MDA之前感染率不同的两个地区：Qalubyia研究区由于之前接受过二乙胺甲嗪治疗，感染率较低；这是 MDA 之前埃及大多数丝虫病流行村庄的典型情况。吉萨研究区的基线感染率很高。我们在村庄进行了反复调查，以了解治疗依从性和微丝蚴血症检测。以及循环丝虫抗原血症、学童丝虫抗原 Bm14 抗体以及室内蚊子感染（通过 PCR 评估）。结果 MDA 依从率非常好（>80%）。在吉萨，MDA 后，微丝蚴血症和循环丝虫抗原血症的患病率分别从 11.5% 下降到 1.2%，从 19.0% 下降到 4.8%（p
Background Egypt was one of the first countries to implement a national programme to eliminate lymphatic filariasis based on WHO's strategy of repeated rounds of mass drug administration (MDA) with diethylcarbamazine and albendazole (target population, 2.5 million in 181 localities). We assessed the effect of five yearly rounds of MDA on filariasis in four sentinel villages in Egypt.Methods We studied two areas with different infection rates before MDA: the Qalubyia study area had a low infection rate because of previous treatment with diethylcarbamazine; this was typical of most filariasis-endemic villages in Egypt before MDA. The Giza study area had a high baseline infection rate. We undertook repeated surveys in villages for treatment compliance and tests for microfilaraemia. and circulating filarial antigenaemia, antibodies to filarial antigen Bm14 in schoolchildren, and infections in indoor-resting mosquitoes (assessed by PCR).Findings MDA compliance rates were excellent (>80%). In Giza after MDA, prevalence rates of microfilaraemia and circulating filarial antigenaemia fell from 11.5% to 1.2%, and from 19.0% to 4.8%, respectively (p