Transcranial MR-Guided Histotripsy System.
Transcranial MR-Guided Histotripsy System.
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DOI：
10.1109/tuffc.2021.3068113
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Xu Z
中科院分区：
文献类型：
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作者：
Lu N;Hall TL;Choi D;Gupta D;Daou BJ;Sukovich JR;Fox A;Gerhardson TI;Pandey AS;Noll DC;Xu Z
组织解剖学此前已被证明可以通过体外切除的人类头骨来治疗广泛的部位。在本文中，开发了经颅磁共振（MR）引导的组织解剖（tcMRgHt）系统，并通过切除的人头骨在体内猪脑中进行了表征和测试。内部设计和制造了焦点深度为 15 cm 的 700 kHz、128 元件 MR 兼容相控阵超声换能器。还建造了支撑结构以方便经颅治疗。 tcMRgHt 阵列的声学特征是在自由场中峰值负压高达 137 MPa，通过像差校正的切除人类头骨峰值负压为 72 MPa，在没有像差校正的情况下峰值负压为 48.4 MPa。通过头骨的电子焦点转向范围为横向 33.5 毫米、轴向 50 毫米，可实现高于 26 MPa 空化固有阈值的峰值负压。使用临床 3T MRI 扫描仪中的 SNR、B0 场图和 B1 场图对 tcMRgHt 系统的 MR 兼容性进行定量评估。使用电子聚焦转向的经颅治疗在红细胞模型和通过切除的人头骨进行的体内猪脑中得到了验证。 MRI 证实，在两只猪中，通过人类头骨成功治疗了目标脑组织。到猪安乐死时，目标周围区域没有观察到过度出血或水肿。这些结果证明了使用这种临床前 tcMRgHt 系统在猪模型中进行体内经颅治疗的可行性。
Histotripsy has been previously shown to treat a wide range of locations through excised human skulls in vitro. In this paper, a transcranial magnetic resonance (MR)-guided histotripsy (tcMRgHt) system was developed, characterized, and tested in the in vivo pig brain through an excised human skull. A 700-kHz, 128-element MR-compatible phased-array ultrasound transducer with a focal depth of 15 cm was designed and fabricated in-house. Support structures were also constructed to facilitate transcranial treatment. The tcMRgHt array was acoustically characterized with a peak negative pressure up to 137 MPa in free field, 72 MPa through an excised human skull with aberration correction, and 48.4 MPa without aberration correction. The electronic focal steering range through the skull was 33.5 mm laterally and 50 mm axially, where peak negative pressure above the 26 MPa cavitation intrinsic threshold can be achieved. The MR-compatibility of the tcMRgHt system was assessed quantitatively using SNR, B0 field map, and B1 field map in a clinical 3T MRI scanner. Transcranial treatment using electronic focal steering was validated in red blood cell phantoms and in vivo pig brain through an excised human skull. In two pigs, targeted cerebral tissue was successfully treated through the human skull as confirmed by MRI. Excessive bleeding or edema was not observed in the peri-target zones by the time of pig euthanasia. These results demonstrated the feasibility of using this preclinical tcMRgHt system for in vivo transcranial treatment in a swine model.