Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes
Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes
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DOI：
10.1007/s11130-013-0355-z
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发表时间：
2013-06-01
影响因子：
4
通讯作者：
Barros, Bianca Sacramento
中科院分区：
文献类型：
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作者：
Abrahao, Sheila Andrade;Fonseca Alvarenga Pereira, Rosemary Gualberto;Barros, Bianca Sacramento
本研究旨在评估饮用咖啡对Zucker大鼠糖尿病和代谢综合征临床标志物的影响。将具有代谢综合征的糖尿病Zucker大鼠和对照Zucker大鼠用于体内测试。动物通过管饲法接受每日剂量的咖啡饮料，持续30天。治疗结束后检测血糖、甘油三酯、总胆固醇及其组分、肌酐、尿酸、谷草转氨酶和谷丙转氨酶活性。还分析了尿液中的尿素和肌酐水平。通过合作调节代谢综合征和2型糖尿病，咖啡饮料有助于降低血清葡萄糖，总胆固醇和甘油三酯。结果表明，由于其降血糖和降血脂作用，用烘焙咖啡饮料治疗在保护患有代谢综合征和2型糖尿病的动物方面是有效的。
This study aimed to evaluate the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats. Diabetic Zucker rats with metabolic syndrome and control Zucker rats were used for in vivo tests. The animals received daily doses of coffee drink by gavage for 30 days. After the treatment, the levels of glucose, triglycerides, total cholesterol and fractions, creatinine, uric acid, activity of aspartate aminotransferase and alanine aminotransferase were evaluated. Urea and creatinine levels were also analyzed in urine. By collaborating in the modulation of the metabolic syndrome and diabetes mellitus type 2, coffee drink helped in reducing serum glucose, total cholesterol and triglycerides. The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2.