Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma
Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma
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DOI：
10.1093/ajcp/aqy023
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发表时间：
2018-07-01
影响因子：
3.5
通讯作者：
Gradowski, Joel F.
中科院分区：
文献类型：
--
作者：
Klairmont, Matthew M.;Cheng, Jinjun;Gradowski, Joel F.
目的：描述血管内大 B 细胞淋巴瘤 (ILBCL) 细胞遗传学特征的数据有限。在这里，我们开发了一个全面的核型数据集来识别 ILBCL 中复发性细胞遗传学异常。方法：从机构数据库和文献中鉴定出具有完整细胞遗传学分析的 ILBCL 病例。对合并后的数据进行了系统性审查，以确定是否存在复发性异常。结果：确定了 4 个新病例，并与先前发表在文献中的 25 个核型相结合。核型一致复杂，畸变中位数为 10 个。总共，72.4% 的患者存在涉及 1 号染色体的异常，其中 31.0% 涉及 1p13 或 1q21 的重排； 58.6% 的患者存在涉及 6 号染色体的异常，几乎所有病例都涉及 6q； 34.5%的人存在涉及14号染色体的异常，其中27.6%涉及14q32的重排； 55.2% 的患者存在 18 号染色体异常，其中 37.9% 的患者存在 18 三体性。结论：超过 50% 的 ILBCL 存在涉及 1、6q 和 18 号染色体的复发性细胞遗传学异常。
Objectives: Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL.Methods: Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities.Results: Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4% had abnormalities involving chromosome 1, with 31.0% involving rearrangements of 1p13 or 1q21; 58.6% had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5% had abnormalities involving chromosome 14, with 27.6% involving rearrangements of 14q32; and 55.2% had abnormalities of chromosome 18, with 37.9% harboring trisomy 18.Conclusions: Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL.