Eliciting the T cell fate with Notch.
Eliciting the T cell fate with Notch.
复制标题
用 Notch 诱导 T 细胞命运。
DOI：
10.1016/j.smim.2010.04.011
复制
发表时间：
2010
影响因子：
7.8
通讯作者：
Bhandoola,Avinash
中科院分区：
文献类型：
--
作者：
Sultana,DilAfroz;Bell,JJeremiah;Zlotoff,DanielA;DeObaldia,MariaElena;Bhandoola,Avinash
Multipotent progenitors arrive at the thymus via the blood. Constraining the non-T cell fates of these progenitors while promoting the T cell fate is a major task of the thymus. Notch appears to be the initial trigger for a developmental program that eventually results in T cell lineage commitment. Several downstream targets of Notch are known, but the specific roles of each are poorly understood. A greater understanding of how Notch and other thymic signals direct progenitors to a T cell fate could be useful for translational work. For example, such work could eventually allow for the generation of fully competent T cells in vitro that could supplement the waning T cell numbers and function in the elderly and boost T cell-mediated immunity in patients with immunodeficiency and after stem cell transplantation.
