Phylogenetic evidence for recombination in dengue virus
Phylogenetic evidence for recombination in dengue virus
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DOI：
10.1093/oxfordjournals.molbev.a026121
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发表时间：
1999-03-01
影响因子：
10.7
通讯作者：
Rambaut, A
中科院分区：
文献类型：
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作者：
Holmes, EC;Worobey, M;Rambaut, A
登革（DEN）病毒基因序列的分裂分解分析揭示了广泛的网络化进化，指示重组，DEN-1株之间，但不是在血清型DEN-2，DEN-3，或DEN-4。在DEN-1中，在过去10年中从南美洲取样的两种病毒被鉴定为重组体。为了映射断点并测试其统计支持，我们开发了一种新的最大似然方法。在两个重组体中，发现断点在包膜蛋白的融合肽内的相似位置，表明在这两个菌株的分歧之前发生了单个重组事件。这是登革病毒自然群体中重组的首次报道。
A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.