A RANDOMIZED TRIAL OF COENZYME Q10 IN MITOCHONDRIAL DISORDERS
A RANDOMIZED TRIAL OF COENZYME Q10 IN MITOCHONDRIAL DISORDERS
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DOI：
10.1002/mus.21758
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发表时间：
2010-11-01
期刊：
影响因子：
3.4
通讯作者：
Tarnopolsky, Mark A.
中科院分区：
文献类型：
--
作者：
Glover, Elisa I.;Martin, Joan;Tarnopolsky, Mark A.
病例报告和开放标签研究表明，辅酶Q(10)(CoQ(10))治疗可能对线粒体疾病患者有有益影响；然而，需要进行对照试验来证明其临床有效性。在一项随机、双盲、交叉试验中，30名线粒体细胞病变患者接受了为期60天的1200毫克/天辅酶Q(10)治疗。测定血乳酸、氧化应激尿标志物、体成分、日常生活活动能力、生活质量、前臂握力和氧减饱和度、循环运动心肺功能变量和脑代谢产物。辅酶Q(10)可减轻运动后乳酸的升高，使运动后5分钟的Vo(2)/kg瘦体重增加(P<；0.005)，灰质胆碱类化合物减少(P<；0.05)。中到高剂量辅酶Q(10)治疗60天对循环运动有氧能力和运动后乳酸影响不大，但不影响其他临床相关变量，如力量或静息乳酸。肌肉神经42：739-748,2010
Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a randomized, double-blind, cross-over trial. Blood lactate, urinary markers of oxidative stress, body composition, activities of daily living, quality of life, forearm handgrip strength and oxygen desaturation, cycle exercise cardiorespiratory variables, and brain metabolites were measured. CoQ(10) treatment attenuated the rise in lactate after cycle ergometry, increased (similar to 1.93 ml) Vo(2)/kg lean mass after 5 minutes of cycling (P < 0.005), and decreased gray matter choline-containing compounds (P < 0.05). Sixty days of moderate- to high-dose CoQ(10) treatment had minor effects on cycle exercise aerobic capacity and post-exercise lactate but did not affect other clinically relevant variables such as strength or resting lactate. Muscle Nerve 42: 739-748, 2010