Effects of acute versus chronic L-carnitine L-tartrate supplementation on metabolic responses to steady state exercise in males and females
Effects of acute versus chronic L-carnitine L-tartrate supplementation on metabolic responses to steady state exercise in males and females
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DOI：
10.1123/ijsnem.15.4.386
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发表时间：
2005-08-01
影响因子：
2.5
通讯作者：
Galloway, SDR
中科院分区：
文献类型：
--
作者：
Abramowicz, WN;Galloway, SDR
12名健康运动受试者(男6名，女6名)在补充L肉碱酒石酸L或安慰剂后，进行3次60min的运动(60%最大摄氧量)。在随机双盲交叉设计中，每个受试者都接受了慢性剂量、急性剂量和安慰剂。在每次试验前重复2d的饮食摄入量和运动。在男性中，服用安慰剂和慢性试验之间的碳水化合物(CHO)氧化速率有显著差异(P=0.02)，但在服用安慰剂和急性试验中没有显著差异(P=0.70)，而且长期补充与安慰剂相比，总CHO氧化更大(平均+/-标准差)，分别为93.8(17.3)g/小时和78.2(23.3)g/h。在女性中，试验之间没有观察到CHO氧化率或总氧化率的差异。对脂肪氧化或血液学反应没有影响的性别组。在这些实验条件下，长期补充LCLT会增加运动中男性的CHO氧化，但在女性中没有观察到这一点。
Twelve healthy active subjects (6 male, 6 female) performed 60 min of exercise (60% VO2max) on 3 occasions after supplementing with L-Carnitine L-tartrate (LCLT) or placebo. Each Subject received a chronic dose, an acute dose, and placebo in a randomized, double-blind crossover design. Dietary intake and exercise were replicated for 2 d prior to each trial. In males there was a significant difference in rate of carbohydrate (CHO) oxidation between placebo and chronic trials (P = 0.02) but not placebo and acute trials (P = 0.70), and total CHO oxidation was greater following chronic supplementation vs. placebo (mean +/- standard deviation) of 93.8 (17.3) g/hr and 78.2 (23.3) g/h, respectively). In females, no difference in rate of, or total, CHO oxidation was observed between trials. No effects on fat oxidation or hematological responses were noted in either gender group. Under these experimental conditions, chronic LCLT supplementation increased CHO oxidation in males during exercise but this was not observed in females.