Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa.
Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa.
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DOI：
10.1002/anie.201400048
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发表时间：
2014-06
影响因子：
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通讯作者：
Zhen‐Long Wu;Bingxin Zhao;Xiao‐Jun Huang;Genyun Tang;Lei Shi;R. Jiang;Xin Liu;Ying Wang;W. Ye
中科院分区：
文献类型：
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作者：
Zhen‐Long Wu;Bingxin Zhao;Xiao‐Jun Huang;Genyun Tang;Lei Shi;R. Jiang;Xin Liu;Ying Wang;W. Ye
Suffrutines A（1）和B（2）是一对新型光化学Z/E异构体中氮茚生物碱，具有独特且高度共轭的C20骨架，从火绒根中分离得到。通过核磁共振谱和单晶X-射线衍射分析确定了化合物的结构。光诱导的异构化和假设的生物遗传途径1和2，以及它们的活性调节神经元-2a细胞的形态进行了讨论。
Suffrutines A (1) and B (2), a pair of novel photochemical Z/E isomeric indolizidine alkaloids, with a unique and highly conjugated C20 skeleton, were isolated from the roots of Flueggea suffruticosa. The structures were elucidated by extensive analysis of NMR spectra and single-crystal X-ray diffraction. The light-induced isomerization and hypothetical biogenetic pathway to 1 and 2, as well as their activity for regulating the morphology of Neuro-2a cells are also discussed.