Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes
Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes
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DOI：
10.1016/s0002-9394(98)00145-7
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发表时间：
1998-07-01
影响因子：
4.2
通讯作者：
Gass, JDM
中科院分区：
文献类型：
--
作者：
Grossniklaus, HE;Gass, JDM
目的：相关的1型（视网膜下色素上皮细胞）和2型（感觉下视网膜）脉络膜新生血管的组织学和临床分类：10例手术切除的脉络膜新生血管，常规处理，并可以被组织学分类为具有1型或2型配置进行了研究。根据术前双眼眼底表现和患者年龄将患者临床分为1型或2型脉络膜新生血管。结果：1型3例，2型7例，分别行组织学和临床分型。10例中有9例的临床分类与组织学分类相匹配。区分2型脉络膜新生血管的临床眼底特征包括脉络膜新生血管区域的视网膜下色素晕或色素斑以及清晰的边界。1型膜的患者平均年龄（76岁）比2型膜（53岁）的患者。结论：它通常是可能的临床确定的临床眼底外观和患者的年龄是否中心凹下脉络膜新生血管代表1型或2型配置。(C)1998年，Elsevier Science Inc. All rights reserved.
Purpose: To correlate the histologic and clinical classification of type 1 (subretinal pigment epithelium) and type 2 (subsensory retina) choroidal neovascularization.Methods: Ten eyes of 10 patients with surgically excised choroidal neovascularization that were routinely processed and could be histologically classified as having a type 1 or type 2 configuration were studied. The patients were clinically classified as having type 1 or type 2 choroidal neovascularization according to preoperative fundus appearance of both eyes and patient age. The histologic and clinical classifications were made in a masked fashion, and the results were compared.Results: The histologic classification was type 1 and type 2 for three and seven specimens, respectively. The clinical classification matched the histologic classification in nine of 10 cases, Clinical fundus characteristics that distinguished type 2 choroidal neovascularization included a subretinal pigmented halo or pigmented plaque in the area of the choroidal neovascularization and sharply defined borders. Patients with type 1 membranes were on average older (76 years) than patients with type 2 membranes (53 years).Conclusions: It is generally possible to clinically ascertain by clinical fundus appearance and age of a patient whether subfoveal choroidal neovascularization represents a type 1 or type 2 configuration. (C) 1998 by Elsevier Science Inc. All rights reserved.