Early and late auditory event-related potentials in cognitively high functioning male adolescents with autism spectrum disorder
Early and late auditory event-related potentials in cognitively high functioning male adolescents with autism spectrum disorder
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DOI：
10.1016/j.rasd.2013.03.007
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发表时间：
2013-07-01
影响因子：
2.5
通讯作者：
Lundervold, Astri J.
中科院分区：
文献类型：
--
作者：
Andersson, Stein;Posserud, Maj-Britt;Lundervold, Astri J.
事件相关电位（ERP）研究在表征自闭症谱系障碍（asd）异常感觉加工和识别的基本性质方面提供了不同的结果。在本研究中，我们报告了来自听觉怪球范式的持续时间错配负性（MMN）和后期ERP成分（P3 a和P3b），这些成分来自认知高功能男性自闭症青少年的同质样本。我们发现，与对照组相比，额叶和颞叶MMN振幅显著降低，P3a或P3b振幅或潜伏期没有差异。这些发现与最近报道的听觉刺激下ERP振幅增强的研究相反，并且更支持弱化的自动听觉感觉处理是ASD中常见的异常听觉行为反应的核心。(C) 2013 Elsevier Ltd.版权所有。
Event-related potentials (ERP) studies have offered diverging results in characterizing the basic nature of abnormal sensory processing and discrimination in autism spectrum disorders (ASDs). In the present study we report duration mismatch negativity (MMN) and later ERP components (P3 a and P3b) derived from auditory odd-ball paradigms in a homogenous sample of cognitively high functioning male adolescents with ASD. We find significantly reduced frontal and temporal MMN amplitudes and no differences in P3a or P3b amplitudes or latencies compared to controls. These findings are in contrast to recent studies reporting enhanced ERP amplitudes to auditory stimuli, and are more in support of a weakened automatic auditory sensory processing as being central to the abnormal auditory behavioral responses commonly encountered in ASD. (C) 2013 Elsevier Ltd. All rights reserved.