Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis.
Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis.
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微生物群、上皮细胞、炎症和 TGF-β 信号转导：肿瘤发生中复杂的相互作用
DOI：
10.3389/fmicb.2018.01353
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发表时间：
2018
影响因子：
5.2
通讯作者：
Liang XH
中科院分区：
文献类型：
--
作者：
Pang X;Tang YJ;Ren XH;Chen QM;Tang YL;Liang XH
微生物区系被广泛认为在人类癌症的发生中起着关键作用。最近的证据表明，在癌变过程中，微生物区系、上皮屏障和炎症形成了一个紧密相关的三角关系。因此，我们讨论了微生物区系失调、上皮屏障功能障碍和免疫反应失调之间的三角关系，以阐明微生物区系致癌的机制，特别是强调了转化生长因子-β信号与致癌三角的每一边之间的相互串扰。这种复杂的相互作用将提供对癌症发生的基本机制的洞察，并可能为癌症预防和治疗干预带来新的希望。
Microbiota has been widely considered to play a critical role in human carcinogenesis. Recent evidence demonstrated that microbiota, epithelial barrier and inflammation has made up a tightly interdependent triangle during the process of carcinogenesis. Hence, we discussed the triangle relationship of microbiota dysbiosis, epithelial barrier dysfunction and dysregulated immune responses to elucidate the mechanisms by which microbiota induces carcinogenesis, especially highlighting the reciprocal crosstalk between transforming growth factor-β signaling and every side of the tumorigenic triangle. This sophisticated interaction will provide insight into the basic mechanisms of carcinogenesis and may bring new hope to cancer prevention and therapeutic intervention.