Developments in STD/HIV interactions: The intertwining epidemics of HIV and HSV-2
Developments in STD/HIV interactions: The intertwining epidemics of HIV and HSV-2
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DOI：
10.1016/j.idc.2005.04.005
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发表时间：
2005-06-01
影响因子：
4.4
通讯作者：
Quinn, TC
中科院分区：
文献类型：
--
作者：
Reynolds, SJ;Quinn, TC
尽管有雄心勃勃的全球预防计划，但在过去20年里，全球仍有超过7500万人感染了艾滋病毒。目前有4000万艾滋病毒携带者，超过3500万人死于艾滋病。艾滋病毒的传播主要是通过性交，较少的病例可归因于静脉吸毒和受污染的输血。这些令人震惊的数字掩盖了这样一个事实，即艾滋病毒通过性行为传播的效率很低，可能只有1000次性行为中有1次是罕见的。性传播疾病，特别是溃疡性生殖器疾病，增加了对艾滋病毒感染的传染性和易感性。来自国际和国内研究的数据越来越多地表明，单纯疱疹病毒2型(HSV-2)是促进艾滋病毒感染传播的主要辅助因素。本文综述了这一重要相互作用的最新进展以及针对HSV-2的不同干预策略的潜在影响。
More than 75 million people worldwide have been infected with HIV over the past 2 decades despite ambitious global prevention programs. Currently 40 million people are living with HIV and over 35 million have died from AIDS. The spread of HIV has been primarily through sexual intercourse with a lesser proportion of cases attributable to intravenous drug use and contaminated blood transfusions. The alarming numbers camouflage the fact that the HIV virus is spread inefficiently through sexual intercourse, perhaps as infrequently as 1 out of 1000 sexual exposures. Sexually transmitted diseases, particularly ulcerative genital diseases, increase infectiousness and susceptibility to HIV infections. Data from international and domestic studies point increasingly to the role of herpes simplex virus type 2 (HSV-2) as a primary cofactor in facilitating the spread of HIV infection. This article reviews the recent developments in this important interaction and the potential impact of different intervention strategies targeting HSV-2.