Influence of leisure-time physical activity on the relationship between C-reactive protein and hypertension in a community-based elderly population of Japan: The Tsurugaya Project
Influence of leisure-time physical activity on the relationship between C-reactive protein and hypertension in a community-based elderly population of Japan: The Tsurugaya Project
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DOI：
10.1291/hypres.28.747
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发表时间：
2005-09-01
影响因子：
5.4
通讯作者：
Nagatomi, R
中科院分区：
文献类型：
--
作者：
Niu, K;Hozawa, A;Nagatomi, R
有几项研究表明日本人群中C反应蛋白（CRP）和血压（BP）之间存在关联，但尚未考虑体力活动的影响。因此，我们设计了一个横断面调查，以确定是否闲暇时间的体力活动（LTPA）修改CRP和高血压之间的关系，在日本老年人。我们的研究人群包括643名年龄在70岁及以上的受试者，他们测量了CRIP、家庭BP和自我报告的LTPA。LPTA是。分为三个强度水平-步行、快走和运动-并使用问卷调查来估计每个患者的强度水平。高血压定义为家庭收缩压≥ 135 mmHg和/或家庭舒张压≥ 85 mmHg或当前使用抗高血压药物。LTPA水平与CRP和高血压相关。在校正影响CRP和高血压的因素，并额外校正LTPA水平后，高血压患者CRP的95%可信区间为2.21（范围：1.33-3.72）、1.99 CRIP的第二、第三和第四四四分位数的受试者分别是第一四分位数的受试者的1.17-3.42和2.38（1.36-4.21）倍。多元回归模型显示，当排除服用抗高血压药物的受试者时，校正潜在混杂因素后，对数转换的CRP和收缩压BID之间存在显著正相关。这是第一项研究，以澄清CRP和高血压之间的正显着关系是独立的LTPA水平在日本老年人。
There are several studies indicating an association between C-reactive protein (CRP) and blood pressure (BP) in the Japanese population, but the influence of physical activity has not been considered. Therefore, we designed a cross-sectional survey to determine whether leisure-time physical activity (LTPA) modifies the relation between CRP and hypertension among Japanese elderly. Our study population comprised 643 subjects aged 70 years and over in whom CRIP, home BP, and self-reported LTPA were measured. LPTA was. categorized into three levels of intensity-walking, brisk walking, and sports-and a questionnaire was used to estimate the level in each patient. Hypertension was defined as a home systolic BP of 135 mmHg or over and/or home diastolic BP of 85 mmHg or over or current use of antihypertensive agents. LTPA levels were associated with both CRP and hypertension. After adjustment for factors affecting CRP and hypertension, and additional adjustment for LTPA levels, the odds ratio (95% confidence interval) of hypertension by CRP was 2.21 (range: 1.33-3.72), 1.99 (1.17-3.42), and 2.38 (1.36-4.21) times higher in subjects in the second, third, and fourth quartiles of CRIP, as compared to subjects in the first quartile, respectively. A multiple regression model showed a positive and significant relation between log-transformed CRP and systolic BID after adjustment for potential confounding factors when participants taking anti hypertensive medication were excluded. This is the first study to clarify that the positive significant relation between CRP and hypertension was independent of LTPA levels among Japanese elderly.