The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition.
The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition.
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DOI：
10.1155/2012/289243
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Muragaki Y
中科院分区：
文献类型：
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作者：
Gui T;Sun Y;Shimokado A;Muragaki Y
丝裂原活化蛋白激酶（MAPK）通路允许细胞解释外部信号并做出适当反应，特别是在上皮-间充质转化（EMT）期间。EMT是胚胎发育、纤维化和肿瘤进展过程中的一个重要过程，其中上皮细胞获得间充质、成纤维细胞样特性，并表现出细胞间粘附减少和运动性增加。TGF-β信号传导是第一个被描述为EMT诱导剂的途径，并且其与Smad家族的关系已经被很好地表征。对MAPK家族四个成员在不同生物系统中的研究表明，MAPK和TGF-β信号通路相互作用，对分泌额外的生长因子和细胞因子具有协同作用，进而促进EMT。本文综述了MAPK及其级联反应的调控和功能，重点介绍了MAPK与TGF-β信号通路相互作用的机制，并讨论了MAPK在EMT中的作用。
The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond appropriately, especially during the epithelial-mesenchymal transition (EMT). EMT is an important process during embryonic development, fibrosis, and tumor progression in which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. TGF-β signaling is the first pathway to be described as an inducer of EMT, and its relationship with the Smad family is already well characterized. Studies of four members of the MAPK family in different biological systems have shown that the MAPK and TGF-β signaling pathways interact with each other and have a synergistic effect on the secretion of additional growth factors and cytokines that in turn promote EMT. In this paper, we present background on the regulation and function of MAPKs and their cascades, highlight the mechanisms of MAPK crosstalk with TGF-β signaling, and discuss the roles of MAPKs in EMT.