Do age and baseline LDL cholesterol levels determine the effect of regular exercise on plasma lipoprotein cholesterol and apolipoprotein B levels?
Do age and baseline LDL cholesterol levels determine the effect of regular exercise on plasma lipoprotein cholesterol and apolipoprotein B levels?
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DOI：
10.1007/s00421-007-0537-1
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发表时间：
2007-08
影响因子：
3
通讯作者：
T. Angelopoulos;S. Sivo;G. Kyriazis;J. D. Caplan;R. Zoeller;J. Lowndes;R. Seip;P. Thompson
中科院分区：
文献类型：
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作者：
T. Angelopoulos;S. Sivo;G. Kyriazis;J. D. Caplan;R. Zoeller;J. Lowndes;R. Seip;P. Thompson
载脂蛋白 B (apoB) 浓度和年龄与心血管疾病风险增加独立相关。年龄还与 apoB 浓度增加有关。本研究的目的是确定运动对 apoB 的影响并检查年龄和脂蛋白之间的关联。四十一名久坐的人在最大心率的 60% 到 85% 之间锻炼了 6 个月，每周四次，每次 40 分钟。测定三次血脂：训练前、最后一次训练后 24 小时和 72 小时。运动不会改变 apoB（1.2 ± 0.05 g/l 与 1.2 ± 0.05 g/l；P> 0.05）或其他脂质或脂蛋白。当参与者被基线低密度脂蛋白胆固醇（LDLc）隔离时，总胆固醇（TC）在24小时后下降（6.3±0.2mmol/l vs. 6.0±0.2mmol/l，P<0.05），24小时和48小时后LDLc下降（4.3±0.1mg/dl vs. 3.9±0.1和高 LDLc 组为 4.1 ± 0.2 mg/dl，P<0.05)。在低 LDLc 组中，TC（4.4 ± 0.2 mmol/l 对比 4.6 ± 0.2 和 4.6 ± 0.2 mmol/l，P> 0.05）和 LDLc（2.6 ± 0.1 mmol/l 对比 2.8 ± 0.1 和 2.8 ± 0.2 mmol/l，P< 0.05）均升高与基线相比，24 小时后并在 72 小时后仍保持较高水平。年龄不会影响 apoB 或脂蛋白对运动的反应。具有高基线 LDLc 的个体在每次运动中产生的 TC 和 LDLc 急剧减少。
Apolipoprotein B (apoB) concentration and age are independently associated with an increased risk for cardiovascular disease. Age is also associated with increased apoB concentration. The purpose of this study was to determine the effects of exercise on apoB and examine the association between age and lipoproteins. Forty-one sedentary individuals exercised for 6 months, four times/week for 40 min between 60 and 85% of their maximal heart rate. Lipids were determined three times: before training, 24 and 72 h after the last training session. Exercise did not alter apoB (1.2 ± 0.05 g/l vs. 1.2 ± 0.05 g/l;P> 0.05), or other lipids or lipoproteins. When participants were sequestered by baseline low density lipoprotein cholesterol (LDLc), total cholesterol (TC) was decreased at 24 h post (6.3 ± 0.2 mmol/l vs. 6.0 ± 0.2 mmol/l,P< 0.05) and LDLc after 24 and 48 h post (4.3 ± 0.1 mg/dl vs. 3.9 ± 0.1 and 4.1 ± 0.2 mg/dl,P< 0.05) in the high LDLc group. In the low LDLc group both TC (4.4 ± 0.2 mmol/l vs. 4.6 ± 0.2 and 4.6 ± 0.2 mmol/l,P> 0.05) and LDLc (2.6 ± 0.1 mmol/l vs. 2.8 ± 0.1 and 2.8 ± 0.2 mmol/l,P< 0.05) were elevated at 24 h and remained elevated at 72 h post compared to baseline. Age does not affect apoB or lipoproteins in response to exercise. Individuals with high baseline LDLc experienced acute reduction in TC and LDLc produced by each exercise session.