Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes.
Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes.
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DOI：
10.1186/1756-9966-27-31
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发表时间：
2008-08-21
期刊：
影响因子：
--
通讯作者：
Dong Q
中科院分区：
文献类型：
--
作者：
Lu Y;Li CS;Dong Q
多种中药已被证实具有抗肿瘤作用，近年来也有关于中药抗肿瘤作用的临床报道，但大部分报道集中于中药的临床治疗效果，另一方面，有关中药与癌细胞凋亡分子相关的综述却很少，很多科学家无法相信此类中药抗肿瘤作用的临床描述，因为这些描述缺乏分子生物学证据。康莱特（KLT）注射液是采用现代先进制药技术从中药薏苡仁中提取的抗肿瘤新药，也是一种新型双相广谱抗癌药物，美国食品药品监督管理局（FDA）也批准了康莱特的II期试验，测试其治疗非小细胞肺癌的疗效。有研究表明其能抑制部分抗凋亡基因并激活部分促凋亡基因，其注射液是能显着抑制多种肿瘤细胞的抗癌新药之一，因此如何进一步探索康莱特注射液通过影响相关基因促进肿瘤细胞凋亡已成为研究的核心。本文对康莱特与一些肿瘤细胞凋亡分子的关系进行了综述。
Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were focused on the clinical treatment of effectiveness for Chinese herb, on the other hand, review about Chinese herbal related with molecules on cancer-cell-apoptosis was seldom, many scientists could not believe such kinds of clinical describes about anti-tumor effects for Chinese herb, because these describes were lack of molecular biology evidence. Kanglaite(KLT) injection is an anti-tumor new drug which extracts from Chinese medicine-coix seed with modern advanced pharmaceutical technology, it is also a new biphase extended-spectrum anticancer medicine, the food and drug administration(FDA) of United States also approved a phase II trial of KLT to test its efficacy in treating non-small-cell lung cancer. Some studies show it could inhibit some anti-apoptotic gene and activate some pro-apoptotic gene, its injection solution is one of the new anticancer medicine that can significantly inhibit a various kinds of tumor cells, so it has become the core of research that how to further explore KLT injection to promote tumor cell apoptosis by impacting on related genes. In this review, the relationship between KLT and some tumor cell apoptosis molecules had been discussed and reviewed generally.
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影响因子：
3.8
作者：
Flynn, Andrew N.;Buret, Andre G.
通讯作者：
Buret, Andre G.
阿托伐他汀通过caspase-9依赖性途径诱导凋亡：对活化大鼠肝星状细胞的体外研究。
影响因子：
6.7
作者：
Aprigliano, Isabella;Dudas, Joszef;Ramadori, Giuliano;Saile, Bernhard
通讯作者：
Saile, Bernhard
DOI：
10.1590/s1516-31801998000200005
发表时间：
1998-03-01
期刊：
Sao Paulo medical journal = Revista paulista de medicina
影响因子：
--
作者：
Kemp, C;Alberti, V N;de Carvalho, F M
通讯作者：
de Carvalho, F M
影响因子：
6.4
作者：
Iwase, M;Watanabe, H;Nagumo, M
通讯作者：
Nagumo, M
影响因子：
7.2
作者：
Chai, W. S.;Zhu, X. M.;Chen, B. Y.
通讯作者：
Chen, B. Y.