An integrated and sensitive detection platform for magneto-resistive biosensors
An integrated and sensitive detection platform for magneto-resistive biosensors
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DOI：
10.1016/j.bios.2006.09.020
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发表时间：
2007-04-15
影响因子：
12.6
通讯作者：
Veen, J.
中科院分区：
文献类型：
--
作者：
de Boer, B. M.;Kahlman, J. A. H. M.;Veen, J.
提出了一种具有巨磁阻（GMR）传感器的紧凑型生物传感器平台，适用于检测超顺磁性纳米颗粒标记。该平台由一次性生物传感器盒和电子阅读器组成，可实现高分析性能的定量检测，同时具有耐用性、易用性和低成本。为了优化信噪比（SNR），磁性标签在高频下被激发。集成在传感器芯片的硅中的导线用于在传感器表面上产生明确定义的磁场，从而消除了与外部设备机械对准的需要。一个信号调制方案，以获得最佳的检测精度。该平台是可扩展的，可以根据应用程序的具体要求进行调整。实验结果表明，三个珠的300 nm直径可以检测到1500 μ m（2）的传感器表面上的测量时间为1秒。(c)2006 Elsevier B.V.保留所有权利。
A compact biosensor platform with giant magneto-resistive (GMR) sensors suited for the detection of superparamagnetic nanoparticle labels is presented. The platform consist of disposable biosensor cartridges and an electronic reader, which enables quantitative detection with high analytical performance, combined with robustness, ease of use and at low cost. In order to optimise the signal-to-noise ratio (SNR), magnetic labels are excited at high frequency. Wires, integrated in the silicon of the sensor chip are used to generate a well-defined magnetic field on the sensor surface, thus removing the need for mechanical alignment with external apparatus. A signal modulation scheme is applied to obtain optimal detection accuracy. The platform is scalable and can be adapted according to application-specific requirements. Experimental results indicate that three beads of 300 nm diameter can be detected on a sensor surface of 1500 mu m(2) for a measurement time of 1 s. (c) 2006 Elsevier B.V. All rights reserved.