LOW-LEVELS OF SOMATOSTATIN IN HUMAN CSF MARK DEPRESSIVE EPISODES
LOW-LEVELS OF SOMATOSTATIN IN HUMAN CSF MARK DEPRESSIVE EPISODES
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DOI：
10.1016/0306-4530(84)90003-9
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发表时间：
1984-01-01
影响因子：
3.7
通讯作者：
LUNDQVIST, G
中科院分区：
文献类型：
--
作者：
AGREN, H;LUNDQVIST, G
根据研究诊断标准（RDC）和情感性障碍和精神分裂症（SADS）评估表，对85例目前或最近发作的重度抑郁症住院患者的脑脊液中生长抑素样免疫反应性进行了测量。在同一周的调查中进行了几项生物精神病学测试。结果表明，低水平的脑脊液生长抑素是抑郁症发作的状态标志，其特征是外观悲伤，感觉疲倦，失眠和主观无法承认任何外部抑郁诱因。脑脊液生长抑素与血小板单胺氧化酶（MAO）活性呈负相关；MAO活性似乎比生长抑素更能解释忧郁特征的程度。脑脊液中3-甲氧基-4-羟基苯基乙二醇（MHPG）和高香草酸（HVA）的比值也与生长抑素呈负相关。脑脊液黄嘌呤与生长抑素呈正相关。脑脊液生长抑素与血清TSH浓度呈高度显著的曲线相关，但脑脊液生长抑素与血清GH[生长激素]或催乳素，或与地塞米松前后血浆皮质醇无相关性。
Somatostatin-like immunoreactivity was measured in the CSF of 85 inpatients with current or recent episodes of major depressive disorders, diagnosed according to Research Diagnostic Criteria (RDC) as assessed with the Schedule for Affective Disorders and Schizophrenia (SADS). Several biopsychiatric tests were run during the same week of investigation. Results indicate low levels of CSF somatostatin to be a state marker for episodes of depression characterized by sad appearance, feelings of tiredness, insomnia and subjective inability to acknowledge any external precipitants for the depression. CSF somatostatin was negatively related to platelet monoamine oxidase (MAO) activity; MAO activity appeared to account better for the degree of melancholic features than did somatostatin. The ratio between 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in CSF also correlated negatively with somatostatin. A positive relationship was noted between CSF xanthine and somatostatin. There was a highly significant curvilinear correlation between CSF somatostatin and serum TSH concentrations, but no correlations between CSF somatostatin and serum GH [growth hormone] or prolactin, or with plasma cortisol before or after dexamethasone.