shRNA-induced interferon-stimulated gene analysis.
shRNA-induced interferon-stimulated gene analysis.
复制标题
shRNA 诱导的干扰素刺激基因分析。
DOI：
10.1007/978-1-61779-439-1_10
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Witting,ScottR
中科院分区：
文献类型：
--
作者：
Morral,Núria;Witting,ScottR
RNA interference (RNAi) is a cellular mechanism to inhibit the expression of gene products in a highly specific manner. In recent years, RNAi has become the cornerstone of gene function studies, shortening the otherwise long process of target identification and validation. In addition, small interfering RNA (siRNA) and short-hairpin RNA (shRNA) therapies are being developed for the treatment of a variety of human diseases. Despite its huge potential for gene silencing, a hurdle to safe and effective RNAi is the activation of innate immune responses. Induction of innate immunity is dose- and sequence-dependent, and is also influenced by target tissue and delivery vehicle. Research on the molecular mechanisms mediating this response is helping to improve the design of the RNAi molecules. Nevertheless, appropriate testing for the presence of this undesired effect is needed prior to making conclusions on the outcome of the silencing treatment.
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影响因子：
82.9
作者：
Hommel, JD;Sears, RM;DiLeone, RJ
通讯作者：
DiLeone, RJ
DOI：
10.1172/jci23187
发表时间：
2005-03
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
C. Taniguchi;K. Ueki;R. Kahn
通讯作者：
C. Taniguchi;K. Ueki;R. Kahn
影响因子：
4.2
作者：
Morral, N;O'Neal, WK;Langston, C
通讯作者：
Langston, C
影响因子：
--
作者：
Fish RJ;Kruithof EK
通讯作者：
Kruithof EK
老年大鼠脑中辅助依赖性腺病毒载体介导的基因转移。
DOI：
10.1089/104303401750061249
发表时间：
2001
期刊：
Human gene therapy.
影响因子：
--
作者：
Zou,L;Yuan,X;Zhou,H;Lu,H;Yang,K
通讯作者：
Yang,K