Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction.
Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction.
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肠道病毒逃避先天免疫：深入了解病毒与宿主的相互作用
DOI：
10.3390/v8010022
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发表时间：
2016-01-15
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Lei X;Xiao X;Wang J
肠病毒属包括多种重要的人类病原体，如脊髓灰质炎病毒、柯萨奇病毒、肠病毒A71、肠病毒d68和鼻病毒。感染肠病毒可导致多种临床病症，包括脊髓灰质炎、脑膜炎和脑炎、手足口病、急性弛缓性麻痹、腹泻、心肌炎和呼吸系统疾病。ev是一种正义单链RNA病毒，通过视黄酸诱导基因（RIG-I）样受体和toll样受体等病原体识别受体触发宿主抗病毒先天免疫反应的激活。反过来，ev已经发展出复杂的策略来逃避宿主的抗病毒反应。在这篇综述中，我们讨论了宿主先天免疫反应与肠病毒感染之间的相互作用，主要关注宿主免疫检测和对肠病毒感染的保护以及逃避这些抗病毒免疫反应的病毒策略。
Enterovirusgenus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. EVs, which are positive-sense single-stranded RNA viruses, trigger activation of the host antiviral innate immune responses through pathogen recognition receptors such as retinoic acid-inducible gene (RIG-I)-likeand Toll-like receptors. In turn, EVs have developed sophisticated strategies to evade host antiviral responses. In this review, we discuss the interplay between the host innate immune responses and EV infection, with a primary focus on host immune detection and protection against EV infection and viral strategies to evade these antiviral immune responses.