Evolution of synonymous codon usage in metazoans
Evolution of synonymous codon usage in metazoans
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DOI：
10.1016/s0959-437x(02)00353-2
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发表时间：
2002-12-01
影响因子：
4
通讯作者：
Duret, L
中科院分区：
文献类型：
--
作者：
Duret, L
基因组计划产生的海量数据和最近人口遗传学模型的发展使比较序列分析成为检测选择足迹的一种非常强大的方法。对同义密码子用法的研究表明，具有微小表型效应的特征可以通过自然选择来塑造。但是，突变模式和有偏见的基因转换过程的变化使得很难区分选择性和中性的进化过程。
The vast amount of data generated by genome projects and the recent development of population genetics models make comparative sequence analyses a very powerful approach with which to detect the footprints of selection. Studies on synonymous codon usage show that traits with minuscule phenotypic effects can be molded by natural selection. But variations in mutation patterns and processes of biased gene conversion make it difficult to distinguish between selective and neutral evolutionary processes.