Metered-dose inhalers .1. Drug content and particle size distribution of beclomethasone dipropionate
Metered-dose inhalers .1. Drug content and particle size distribution of beclomethasone dipropionate
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DOI：
10.1016/0731-7085(96)01730-x
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发表时间：
1996-05-01
影响因子：
3.4
通讯作者：
Bogard, HA
中科院分区：
文献类型：
--
作者：
LeBelle, M;Pike, RK;Bogard, HA
对四种市售倍氯米松计量吸入器的喷雾含量均匀性和颗粒大小进行了分析。在罐寿命开始时收集的已底漆和未底漆喷雾剂的药物含量与整个实验期间收集的药物含量没有显着差异。使用 Andersen Cascade Impactor Mark II 对四种产品进行的粒度分析表明，分布曲线并不相同。对现有的 HPLC 方法进行了修改，以定量单次喷雾以确保含量均匀性，并测量冲击器台上的量以进行粒度测定。
Four commercially available beclomethasone metered dose inhalers were analyzed for both spray content uniformity and par-tide size. The drug contents of primed and unprimed sprays collected at the beginning of the lifetime of the canister were not significantly different from those collected throughout the experiment. Particle size analysis of the four products using the Andersen Cascade Impactor Mark II showed that the distribution profiles were not identical.An existing HPLC method was modified to quantitate single sprays for content uniformity and to measure the amount on an impactor stage for particle sizing.