An expeditious and high-yield formal synthesis of hirsutene using Rh(I)-catalyzed [(5+2)+1] cycloaddition
An expeditious and high-yield formal synthesis of hirsutene using Rh(I)-catalyzed [(5+2)+1] cycloaddition
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使用 Rh(I) 催化的 [(5 2) 1] 环加成快速、高产率正式合成 hirsuten
DOI：
10.1016/j.tetlet.2008.10.023
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发表时间：
2009-01-14
影响因子：
1.8
通讯作者：
Yu, Zhi-Xiang
中科院分区：
文献类型：
--
作者：
Fan, Xiaohui;Tang, Min-Xian;Yu, Zhi-Xiang
实现了一种快速、高产率地合成毛状毛的方法。该合成方法以Rh(I)催化的[(5+2)+1]环加成反应合成双环辛烯酮为特征，可有效地转化为用于外消旋和不对称合成毛状质的高级中间体双环二酮。(C)2008爱思唯尔有限公司。保留所有权利。
An expeditious and high-yield formal synthesis of hirsutene has been achieved. This synthesis features Rh(I)-catalyzed [(5+2)+1] cycloaddition to construct a bicyclic cyclooctenone, which can be efficiently transformed to bicyclic diketone, an advanced intermediate for racemic and asymmetric syntheses of hirsutene. (C) 2008 Elsevier Ltd. All rights reserved.