Development of the external genitalia and their sexual dimorphic regulation in mice.
Development of the external genitalia and their sexual dimorphic regulation in mice.
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小鼠外生殖器的发育及其性二态性调节。
DOI：
10.1159/000357932
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yamada,Gen
中科院分区：
文献类型：
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作者：
Ipulan,LerrieAnn;Suzuki,Kentaro;Matsushita,Shoko;Suzuki,Hiroko;Okazawa,Mika;Jacinto,Sonia;Hirai,Syu-ichi;Yamada,Gen
外生殖器的研究可分为两个发育阶段：双能生殖结节（GT）的形成和生长以及雌雄GT的性分化。GT分化的第二阶段发生的性二型过程被认为是由雄激素信号和最近与其他信号因子的串扰所控制的。阐明激素信号对GT中其他信号网络的调节机制的过程仍处于早期阶段。然而，它正在成为一个富有成效的研究领域。本文综述了小鼠GT的发展和雄性化GT的定义特征的各种研究，并提出了不同的信号通路可能涉及在雄性化。
The study of the external genitalia is divided into 2 developmental stages: the formation and growth of a bipotential genital tubercle (GT) and the sexual differentiation of the male and female GT. The sexually dimorphic processes, which occur during the second part of GT differentiation, are suggested to be governed by androgen signaling and more recently crosstalk with other signaling factors. The process of elucidating the regulatory mechanisms of hormone signaling towards other signaling networks in the GT is still in its early stages. Nevertheless, it is becoming a productive area of research. This review summarizes various studies on the development of the murine GT and the defining characteristics of a masculinized GT and presents the different signaling pathways possibly involved during masculinization.