Lipogenic gene expression profile in patients with gastric cancer.
Lipogenic gene expression profile in patients with gastric cancer.
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DOI：
10.3892/mco.2013.148
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发表时间：
2013-09
影响因子：
1.2
通讯作者：
Hisatomi H
中科院分区：
文献类型：
--
作者：
Miyachi K;Sawada Y;Shida Y;Sugawara A;Hisatomi H
许多类型的癌症表现出增加的脂肪生成和脂肪生成酶和转录因子的表达，包括固醇调节元件结合蛋白-1。脂肪生成基因表达在mRNA水平上调，与脂肪生成转录因子表达和/或活性变化相关的代谢途径一致。然而，这种表达模式在人类胃癌尚未阐明。在这项研究中，脂肪生成基因在癌组织中的表达进行了研究，采用定量PCR。在胃癌患者中，肉毒碱O-棕榈酰转移酶I型mRNA和miR-33 b显著下调，表明miR-33 b下调是由也影响参与脂肪生成基因表达的转录因子的表达和/或活性的条件介导的。因此，miR-33 b与胃癌的相关性可能为胃癌的基因诊断提供新的策略。然而，需要包括更多样本的额外研究来确认这些结果。
Numerous types of cancer exhibit increased lipogenesis and expression of lipogenic enzymes and transcription factors, including sterol regulatory element-binding protein-1. Lipogenic gene expression is upregulated at the mRNA level, in concert with metabolic pathways associated with changes in expression and/or activity of lipogenic transcription factors. However, this expression pattern in human gastric carcinoma has not been elucidated. In this study, lipogenic gene expression in cancer tissues was investigated using quantitative PCR. In patients with gastric cancer, carnitine O-palmitoyltransferase type I mRNA and miR-33b were significantly downregulated, suggesting that miR-33b downregulation is mediated by conditions that also affect the expression and/or activity of transcription factors involved in lipogenic gene expression. Consequently, the association between miR-33b and gastric cancer may provide a novel strategy for the genetic diagnosis of gastric cancer. However, additional studies including a larger number of samples are required to confirm these results.