DIETARY RESTRICTION OF ADULT MALE RHESUS-MONKEYS - DESIGN, METHODOLOGY, AND PRELIMINARY FINDINGS FROM THE 1ST YEAR OF STUDY
DIETARY RESTRICTION OF ADULT MALE RHESUS-MONKEYS - DESIGN, METHODOLOGY, AND PRELIMINARY FINDINGS FROM THE 1ST YEAR OF STUDY
复制标题
DOI：
10.1093/geronj/48.1.b17
复制
发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
ERSHLER, WB
中科院分区：
文献类型：
--
作者：
KEMNITZ, JW;WEINDRUCH, R;ERSHLER, WB
饮食限制（DR）延缓衰老过程，延长啮齿动物和简单动物的最大寿命。我们在30只成年（8-14岁）雄性恒河猴中开展了一项研究，以确定灵长类动物中成年发病的DR是否会延缓衰老过程，并在此报告实验第一年的结果。在获得基线数据的3-6个月期间后，将15只动物分配到对照组，每天6-8小时自由进食半纯化饲料。另外15只猴子被喂食相同的饮食，但在70%的基线摄入量水平分别预定。每半年对动物的体型和组成、体力活动、代谢率、葡萄糖耐量和胰岛素敏感性、血液学指标、免疫功能和指甲生长进行评价。每年评估眼功能。一年后的初步观察结果是：（a）所有的猴子看起来都非常健康;（B）对照组的平均体重增加了9%，而DR组的猴子没有增加体重;（c）DR组的猴子比对照组的猴子讨厌更少的体脂，而瘦体重的量没有受到DR的显著影响;（d）相对于对照组，DR组猴子的体力活动有少量但统计学显著的减少;（e）DR对其他测量没有明显影响。在研究的第一年，对照组猴子逐渐减少了它们的自愿食物摄入水平，并且相应地调整了对DR猴子的食物分配，以恢复组间30%的预期差异。这些早期数据表明，DR可以安全地建立在成年猴，但需要更长的时间和/或更严重的DR，以确定它是否能够影响长寿灵长类动物的年龄敏感指数。
Dietary restriction (DR) retards aging processes and extends maximum life span in rodents and in simpler animals. We initiated a study in 30 adult (8-14 years old) male rhesus monkeys to determine whether or not aging processes are retarded by adult-onset DR in a primate species and herein report results from the experiment's first year. Following a 3-6 month period when baseline data were obtained, 15 animals were assigned to a control group and given free access to a semipurified diet for 6-8 hours per day. The other 15 monkeys were fed the same diet but at 70% of their baseline intake levels predetermined individually. The animals, are being evaluated semi-annually for body size and composition, physical activity, metabolic rate, glucose tolerance and insulin sensitivity, hematologic indices, immunologic function, and fingernail growth. Ocular function is assessed annually. The preliminary observations after one year are: (a) all monkeys appear to be in excellent health; (b) average body weights for controls increased by 9% while monkeys on DR did not gain weight; (c) monkeys on DR hate less body fat than do control monkeys, whereas the amount of lean body mass has not been significantly influenced by DR; (d) there was a small but statistically significant reduction in physical activity for monkeys on DR relative to controls; and (e) DR has not overtly influenced the other measures. Control monkeys gradually reduced their voluntary levels of food intake during the first year of study, and food allotments to DR monkeys are being adjusted accordingly in order to reinstate the intended 30% difference between groups. These early data indicate that DR can be safely instituted in adult monkeys, but that longer term and/or more severe DR is required to determine if it is capable of influencing age-sensitive indices in long-lived primates.