A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth
A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth
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lncRNA微调水杨酸生物合成以平衡植物免疫和生长
DOI：
10.1016/j.chom.2022.07.001
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发表时间：
2022-08-10
影响因子：
30.3
通讯作者：
Zhang, Xiaoming
中科院分区：
文献类型：
--
作者：
Liu, Ningkun;Xu, Yanzhuo;Zhang, Xiaoming
植物免疫的结构性激活不利于植物的生长发育。在这里，我们揭示了一个长的非编码RNA(LncRNA)在微调植物免疫和生长平衡中的作用。我们发现一种名为水杨酸生物发生控制器1(SABC1)的lncRNA抑制健康植物的免疫并促进其生长。SABC1将多梳抑制复合体2招募到其邻近基因NAC3，NAC3编码NAC转录因子。通过H3K27me3降低NAC3转录。NAC3激活水杨酸(SA)生物合成的关键酶--异支酸合成酶1(ICS1)的转录。因此，SABC1通过减少NAC3和ICS/转录来抑制SA的产生和植物免疫。在病原体侵染时，SABC1被下调以降低植物对细菌和病毒的抗性。综上所述，我们的发现表明，lncRNA SABC1通过调节SA的生物合成，在平衡植物防御和生长方面起着分子开关的作用。
Constitutive activation of plant immunity is detrimental to plant growth and development. Here, we uncover the role of a long non-coding RNA (lncRNA) in fine-tuning the balance of plant immunity and growth. We find that a lncRNA termed salicylic acid biogenesis controller 1 (SABC1) suppresses immunity and promotes growth in healthy plants. SABC1 recruits the polycomb repressive complex 2 to its neighboring gene NAC3, which encodes a NAC transcription factor. to decrease NAC3 transcription via H3K27me3. NAC3 activates the transcription of isochorismate synthase 1 (ICS1), a key enzyme catalyzing salicylic acid (SA) biosynthesis. SABC1 thus represses SA production and plant immunity via decreasing NAC3 and ICS/transcriptions. Upon pathogen infection, SABC1 is downregulated to derepress plant resistance to bacteria and viruses. Together, our findings reveal lncRNA SABC1 as a molecular switch in balancing plant defense and growth by modulating SA biosynthesis.