Computational challenges of systems biology
Computational challenges of systems biology
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DOI：
10.1109/mc.2004.1297236
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发表时间：
2004-05-01
期刊：
影响因子：
2.2
通讯作者：
Warner, A
中科院分区：
文献类型：
--
作者：
Finkelstein, A;Hetherington, J;Warner, A
通过提出新的计算挑战和扩展最先进的技术，生物信息学已经成为生物学分子革命的计算响应。但生物信息学只是重塑生命科学的第一步。为了取得进一步的进展，我们必须回到整个生物系统的研究上来：心脏、心血管系统、大脑和肝脏。系统生物学的进步需要计算机科学家与生命科学家和数学家密切合作。与分子生物学革命相反，计算机科学将积极参与塑造系统生物学。要获得的奖励是巨大的，从计算机药物设计和测试到考虑生理学和遗传特征的个性化药物。
By posing novel computational challenges and stretching the state of the art, bioinformatics has become the computing response to the molecular revolution in biology. But bioinformatics is only the first step in reshaping the life sciences. For further progress we must return to the study of whole biological systems: the heart, cardiovascular system, brain, and liver.Progress in systems biology will require computer scientists to work closely with life scientists and mathematicians. In contrast to the molecular biology revolution, computer science will actively engage in shaping systems biology. The prize to be attained is immense, ranging from in silico drug design and testing to individualized medicine that takes into account physiology and genetic profiles.