Identification of genetically mediated cortical networks: A multivariate study of pediatric twins and siblings
Identification of genetically mediated cortical networks: A multivariate study of pediatric twins and siblings
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DOI：
10.1093/cercor/bhm211
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发表时间：
2008-08-01
期刊：
影响因子：
3.7
通讯作者：
Giedd, J. N.
中科院分区：
文献类型：
--
作者：
Schmitt, J. E.;Lenroot, R. K.;Giedd, J. N.
采用结构方程模型和选择的多变量方法分析了308例双胞胎、64例双胞胎兄弟姐妹和228例单胞胎的结构磁共振成像数据，以确定遗传介导的皮质内相关性。主成分分析（PCA）的遗传相关矩阵表明，一个单一的因素占60%以上的遗传变异皮层厚度。当协变的平均全球皮质厚度，PCA，聚类分析和图形模型确定遗传介导的额顶叶和枕叶网络。图论模型表明，观察到的遗传介导的关系遵循小世界的建筑规则。这些发现在很大程度上与其他多变量研究的大脑结构和功能，双胞胎文献，以及目前的理解在皮质神经发育的基因的作用是一致的。
Structural magnetic resonance imaging data from 308 twins, 64 singleton siblings of twins, and 228 singletons were analyzed using structural equation modeling and selected multivariate methods to identify genetically mediated intracortical associations. Principal components analyses (PCA) of the genetic correlation matrix indicated a single factor accounting for over 60% of the genetic variability in cortical thickness. When covaried for mean global cortical thickness, PCA, cluster analyses, and graph models identified genetically mediated fronto-parietal and occipital networks. Graph theoretical models suggest that the observed genetically mediated relationships follow small world architectural rules. These findings are largely concordant with other multivariate studies of brain structure and function, the twin literature, and current understanding on the role of genes in cortical neurodevelopment.